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Fully automated light transmission aggregometry on a disc for platelet function tests

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dc.contributor.authorChi-Ju Kim-
dc.contributor.authorJungmin Kim-
dc.contributor.authorJonathan Sabaté del Río-
dc.contributor.authorDong Yeob Ki-
dc.contributor.authorJunyoung Kim-
dc.contributor.authorYoon-Kyoung Cho-
dc.date.accessioned2021-12-02T04:50:05Z-
dc.date.available2021-12-02T04:50:05Z-
dc.date.created2021-11-29-
dc.date.issued2021-11-25-
dc.identifier.issn1473-0197-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10748-
dc.description.abstractPlatelet function tests, a group of assays that measure the ability of platelets to aggregate and promote clotting in a sample of blood, are performed in various medical fields to assess inherited platelet function disorders and monitor antiplatelet therapies. Light transmission aggregometry (LTA) is considered the gold standard for platelet function assessment. However, the lack of a standardized protocol is a major drawback when applied at the point of care. Moreover, it is a time-consuming and labor-intensive assay that requires a large volume of blood. Here, we describe the design, fabrication, and operation of a centrifugal microfluidic disc that can perform a fully automated LTA assay from a small volume of a whole blood sample (<1 mL), achieving highly reproducible results (3.2% coefficient of variation) within a short period (<25 min). The assays performed with this device yield more precise and accurate results than traditional LTA because of the automation of the reaction steps, minimal human operation, robust detection strategy via the distinctive structure of the microfluidic chamber, and quick analysis that minimizes the adverse effects of platelet instability.-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleFully automated light transmission aggregometry on a disc for platelet function tests-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000716095500001-
dc.identifier.scopusid2-s2.0-85120406006-
dc.identifier.rimsid76779-
dc.contributor.affiliatedAuthorChi-Ju Kim-
dc.contributor.affiliatedAuthorJungmin Kim-
dc.contributor.affiliatedAuthorJonathan Sabaté del Río-
dc.contributor.affiliatedAuthorDong Yeob Ki-
dc.contributor.affiliatedAuthorJunyoung Kim-
dc.contributor.affiliatedAuthorYoon-Kyoung Cho-
dc.identifier.doi10.1039/d1lc00708d-
dc.identifier.bibliographicCitationLAB ON A CHIP, v.21, no.23, pp.4707 - 4715-
dc.relation.isPartOfLAB ON A CHIP-
dc.citation.titleLAB ON A CHIP-
dc.citation.volume21-
dc.citation.number23-
dc.citation.startPage4707-
dc.citation.endPage4715-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaInstruments & Instrumentation-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryInstruments & Instrumentation-
dc.subject.keywordPlusANTIPLATELET AGENTS-
dc.subject.keywordPlusHEALTHY-INDIVIDUALS-
dc.subject.keywordPlusWHOLE-BLOOD-
dc.subject.keywordPlusASPIRIN-
dc.subject.keywordPlusAGGREGATION-
dc.subject.keywordPlusGUIDELINES-
dc.subject.keywordPlusDISORDERS-
dc.subject.keywordPlusCONSENSUS-
dc.subject.keywordPlusAGONISTS-
dc.subject.keywordPlusCOUNT-
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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