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Somya, Mani
첨단연성물질 연구단
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A topological look into the evolution of developmental programs

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Title
A topological look into the evolution of developmental programs
Author(s)
Somya Mani; Tsvi Tlusty
Publication Date
2021-10-05
Journal
Biophysical Journal, v.120, no.19, pp.4193 - 4201
Publisher
Biophysical Society
Abstract
© 2021 Biophysical SocietyRapid advance of experimental techniques provides an unprecedented in-depth view into complex developmental processes. Still, little is known on how the complexity of multicellular organisms evolved by elaborating developmental programs and inventing new cell types. A hurdle to understanding developmental evolution is the difficulty of even describing the intertwined network of spatiotemporal processes underlying the development of complex multicellular organisms. Nonetheless, an overview of developmental trajectories can be obtained from cell type lineage maps. Here, we propose that these lineage maps can also reveal how developmental programs evolve: the modes of evolving new cell types in an organism should be visible in its developmental trajectories and therefore in the geometry of its cell type lineage map. This idea is demonstrated using a parsimonious generative model of developmental programs, which allows us to reliably survey the universe of all possible programs and examine their topological features. We find that, contrary to belief, tree-like lineage maps are rare, and lineage maps of complex multicellular organisms are likely to be directed acyclic graphs in which multiple developmental routes can converge on the same cell type. Although cell type evolution prescribes what developmental programs come into existence, natural selection prunes those programs that produce low-functioning organisms. Our model indicates that additionally, lineage map topologies are correlated with such a functional property: the ability of organisms to regenerate.
URI
https://pr.ibs.re.kr/handle/8788114/10450
DOI
10.1016/j.bpj.2021.08.044
ISSN
0006-3495
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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