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Cho, Yoon-Kyoung
첨단연성물질 연구단
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The role of liquid biopsies in prostate cancer management

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Title
The role of liquid biopsies in prostate cancer management
Author(s)
Kim, Chi-Ju; Dong, Liang; Amend, Sarah R.; Cho, Yoon-Kyoung; Pienta, Kenneth J.
Publication Date
2021-09
Journal
LAB ON A CHIP, v.21, no.17, pp.3263 - 3288
Publisher
ROYAL SOC CHEMISTRY
Abstract
Liquid biopsy has emerged as a complement to invasive tissue biopsy to guide cancer diagnosis and treatment. The common liquid biopsy biomarkers are circulating tumor cells (CTCs), extracellular vesicles (EVs), and circulating tumor DNA (ctDNA). Each biomarker provides specific information based on its intrinsic characteristics. Prostate cancer is the second most common cancer in males worldwide. In men with low-grade localized prostate cancer, the disease can often be managed by active surveillance. For men who require treatment, the 5-year survival rate of localized prostate cancer is the highest among all cancer types, but the metastatic disease remains incurable. Metastatic prostate cancer invariably progresses to involve multiple bone sites and develops into a castration-resistant disease that leads to cancer death. The need to appropriately diagnose and guide the serial treatment of men with prostate cancer has led to the implementation of many studies to apply liquid biopsies to prostate cancer management. This review describes recent advancements in isolation and detection technology and the strength and weaknesses of the three circulating biomarkers. The clinical studies based on liquid biopsy results are summarized to depict the future perspective in the role of liquid biopsy on prostate cancer management.
URI
https://pr.ibs.re.kr/handle/8788114/10439
DOI
10.1039/d1lc00485a
ISSN
1473-0197
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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