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혈관 연구단
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Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

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Title
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19
Author(s)
Ji Hoon Ahn; JungMo Kim; Seon Pyo Hong; Choi, Sung Yong; Myung Jin Yang; Ju, Young Seok; Kim, Young Tae; Ho Min Kim; Rahman, Tazikur; Chung, Man Ki; Hong, Sang Duk; Hosung Bae; Lee, Chang-Seop; Gou Young Koh
Publication Date
2021-07
Journal
Journal of Clinical Investigation, v.131, no.13
Publisher
American Society for Clinical Investigation
Abstract
© 2021, American Society for Clinical Investigation.The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation.
URI
https://pr.ibs.re.kr/handle/8788114/10335
DOI
10.1172/JCI148517
ISSN
0021-9738
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
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