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Ji Hoon, Ahn
혈관 연구단
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Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

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dc.contributor.authorJi Hoon Ahn-
dc.contributor.authorJungMo Kim-
dc.contributor.authorSeon Pyo Hong-
dc.contributor.authorChoi, Sung Yong-
dc.contributor.authorMyung Jin Yang-
dc.contributor.authorJu, Young Seok-
dc.contributor.authorKim, Young Tae-
dc.contributor.authorHo Min Kim-
dc.contributor.authorRahman, Tazikur-
dc.contributor.authorChung, Man Ki-
dc.contributor.authorHong, Sang Duk-
dc.contributor.authorHosung Bae-
dc.contributor.authorLee, Chang-Seop-
dc.contributor.authorGou Young Koh-
dc.date.accessioned2021-10-05T07:30:05Z-
dc.date.available2021-10-05T07:30:05Z-
dc.date.created2021-08-09-
dc.date.issued2021-07-01-
dc.identifier.issn0021-9738-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10335-
dc.description.abstract© 2021, American Society for Clinical Investigation.The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation.-
dc.language영어-
dc.publisherAmerican Society for Clinical Investigation-
dc.titleNasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000675858200007-
dc.identifier.scopusid2-s2.0-85109049583-
dc.identifier.rimsid76166-
dc.contributor.affiliatedAuthorJi Hoon Ahn-
dc.contributor.affiliatedAuthorJungMo Kim-
dc.contributor.affiliatedAuthorSeon Pyo Hong-
dc.contributor.affiliatedAuthorMyung Jin Yang-
dc.contributor.affiliatedAuthorHo Min Kim-
dc.contributor.affiliatedAuthorHosung Bae-
dc.contributor.affiliatedAuthorGou Young Koh-
dc.identifier.doi10.1172/JCI148517-
dc.identifier.bibliographicCitationJournal of Clinical Investigation, v.131, no.13-
dc.relation.isPartOfJournal of Clinical Investigation-
dc.citation.titleJournal of Clinical Investigation-
dc.citation.volume131-
dc.citation.number13-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusEXPRESSION-
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
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