BROWSE

Related Scientist

CNCR's photo.

CNCR
나노물질 및 화학반응 연구단
more info

ITEM VIEW & DOWNLOAD

Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering

Cited 0 time in webofscience Cited 0 time in scopus
14 Viewed 0 Downloaded
Title
Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering
Author(s)
Yunbeom Lee; Jong Goo Kim; Sang Jin Lee; Srinivasan Muniyappan; Tae Wu Kim; Hosung Ki; Hanui Kim; Junbeom Jo; So Ri Yun; Hyosub Lee; Kyung Won Lee; Seong Ok Kim; Marco Cammarata; Hyotcherl Ihee
Subject
TIME-RESOLVED CRYSTALLOGRAPHY, ; STRUCTURAL DYNAMICS, ; LIGAND MIGRATION, ; DIMERIC HEMOGLOBIN, ; PROTEIN QUAKE, ; BINDING, ; PHOTODISSOCIATION, ; KINETICS, ; CAVITIES
Publication Date
2021-06-16
Journal
NATURE COMMUNICATIONS, v.12, no.1
Publisher
Nature Research
Abstract
© 2021, The Author(s).Ultrafast motion of molecules, particularly the coherent motion, has been intensively investigated as a key factor guiding the reaction pathways. Recently, X-ray free-electron lasers (XFELs) have been utilized to elucidate the ultrafast motion of molecules. However, the studies on proteins using XFELs have been typically limited to the crystalline phase, and proteins in solution have rarely been investigated. Here we applied femtosecond time-resolved X-ray solution scattering (fs-TRXSS) and a structure refinement method to visualize the ultrafast motion of a protein. We succeeded in revealing detailed ultrafast structural changes of homodimeric hemoglobin involving the coherent motion. In addition to the motion of the protein itself, the time-dependent change of electron density of the hydration shell was tracked. Besides, the analysis on the fs-TRXSS data of myoglobin allows for observing the effect of the oligomeric state on the ultrafast coherent motion.
URI
https://pr.ibs.re.kr/handle/8788114/10019
DOI
10.1038/s41467-021-23947-7
ISSN
2041-1723
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse