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면역미생물공생연구단
면역 미생물 공생 연구단
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CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice

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Title
CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice
Author(s)
Kim D.; Kim J.; Yoon J.H.; Ghim J.; Yea K.; Song P.; Park S.; Lee A.; Chun-Pyo Hong; Min Seong Jang; Kwon Y.; Park S.; Myoung Ho Jang; Berggren P.-O.; Suh P.-G.; Ryu S.H.
Publication Date
2014-07
Journal
DIABETOLOGIA, v.57, no.7, pp.1456 - 1465
Publisher
SPRINGER
Abstract
Aims/hypothesis Obesity-induced inflammation is initiated by the recruitment of macrophages into adipose tissue. The recruited macrophages, called adipose tissue macrophages, secrete several proinflammatory cytokines that cause low-grade systemic inflammation and insulin resistance. The aim of this study was to find macrophage-recruiting factors that are thought to provide a crucial connection between obesity and insulin resistance. Methods We used chemotaxis assay, reverse phase HPLC and tandem MS analysis to find chemotactic factors from adipocytes. The expression of chemokines and macrophage markers was evaluated by quantitative RT-PCR, immunohistochemistry and FACS analysis. Results We report our finding that the chemokine (C-X-C motif) ligand 12 (CXCL12, also known as stromal cellderived factor 1), identified from 3T3-L1 adipocyte conditioned medium, induces monocyte migration via its receptor chemokine (C-X-C motif) receptor 4 (CXCR4). Diet-induced obese mice demonstrated a robust increase of CXCL12 expression in white adipose tissue (WAT). Treatment of obese mice with a CXCR4 antagonist reduced macrophage accumulation and production of proinflammatory cytokines in WAT, and improved systemic insulin sensitivity. Conclusions/interpretation In this study we found that CXCL12 is an adipocyte-derived chemotactic factor that recruits macrophages, and that it is a required factor for the establishment of obesity-induced adipose tissue inflammation and systemic insulin resistance.
URI
https://pr.ibs.re.kr/handle/8788114/990
ISSN
0012-186X
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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