NEW ENGLAND JOURNAL OF MEDICINE, v.384, no.14, pp.1364 - 1366
Publisher
MASSACHUSETTS MEDICAL SOC
Abstract
The Hutchinson?Gilford progeria syndrome is an autosomal dominant disease caused by a single point mutation in LMNA, which encodes the lamin A and C proteins. Recent experiments have shown that life span in a mouse model of the disease was extended through DNA base editing.