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Goal-directed interaction of stimulus and task demand in the parahippocampal region

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Title
Goal-directed interaction of stimulus and task demand in the parahippocampal region
Author(s)
Lee, Su-Min; Jin, Seung-Woo; Park, Seong-Beom; Park, Eun-Hye; Choong-Hee Lee; Lee, Hyun-Woo; Lim, Heung-Yeol; Yoo, Seung-Woo; Ahn, Jae Rong; Shin, Jhoseph; Lee, Sang Ah; Lee, Inah
Publication Date
2021-07
Journal
HIPPOCAMPUS, v.31, no.7, pp.717 - 736
Publisher
WILEY
Abstract
The hippocampus and parahippocampal region are essential for representing episodic memories involving various spatial locations and objects, and for using those memories for future adaptive behavior. The "dual-stream model" was initially formulated based on anatomical characteristics of the medial temporal lobe, dividing the parahippocampal region into two streams that separately process and relay spatial and nonspatial information to the hippocampus. Despite its significance, the dual-stream model in its original form cannot explain recent experimental results, and many researchers have recognized the need for a modification of the model. Here, we argue that dividing the parahippocampal region into spatial and nonspatial streams a priori may be too simplistic, particularly in light of ambiguous situations in which a sensory cue alone (e.g., visual scene) may not allow such a definitive categorization. Upon reviewing evidence, including our own, that reveals the importance of goal-directed behavioral responses in determining the relative involvement of the parahippocampal processing streams, we propose the Goal-directed Interaction of Stimulus and Task-demand (GIST) model. In the GIST model, input stimuli such as visual scenes and objects are first processed by both the postrhinal and perirhinal cortices-the postrhinal cortex more heavily involved with visual scenes and perirhinal cortex with objects-with relatively little dependence on behavioral task demand. However, once perceptual ambiguities are resolved and the scenes and objects are identified and recognized, the information is then processed through the medial or lateral entorhinal cortex, depending on whether it is used to fulfill navigational or non-navigational goals, respectively. As complex sensory stimuli are utilized for both navigational and non-navigational purposes in an intermixed fashion in naturalistic settings, the hippocampus may be required to then put together these experiences into a coherent map to allow flexible cognitive operations for adaptive behavior to occur.
URI
https://pr.ibs.re.kr/handle/8788114/9814
DOI
10.1002/hipo.23295
ISSN
1050-9631
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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