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분자 분광학 및 동력학 연구단
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Sequence-dependent cost for Z-form shapes the torsion-driven B-Z transition via close interplay of Z-DNA and DNA bubble

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dc.contributor.authorSook Ho Kim-
dc.contributor.authorHae Jun Jung-
dc.contributor.authorIl-Buem Lee-
dc.contributor.authorNam-Kyung Lee-
dc.contributor.authorSeok-Cheol Hong-
dc.date.accessioned2021-06-22T00:30:04Z-
dc.date.accessioned2021-06-22T00:30:04Z-
dc.date.available2021-06-22T00:30:04Z-
dc.date.available2021-06-22T00:30:04Z-
dc.date.created2021-05-27-
dc.date.issued2021-04-
dc.identifier.issn0305-1048-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9794-
dc.description.abstractDespite recent genome-wide investigations of functional DNA elements, the mechanistic details about their actions remain elusive. One intriguing possibility is that DNA sequences with special patterns play biological roles, adopting non-B-DNA conformations. Here we investigated dynamics of thymine-guanine (TG) repeats, microsatellite sequences and recurrently found in promoters, as well as cytosine-guanine (CG) repeats, best-known Z-DNA forming sequence, in the aspect of Z-DNA formation. We measured the energy barriers of the B-Z transition with those repeats and discovered the sequence-dependent penalty for Z-DNA generates distinctive thermodynamic and kinetic features in the torque-induced transition. Due to the higher torsional stress required for Z-form in TG repeats, a bubble could be induced more easily, suppressing Z-DNA induction, but facilitate the B-Z interconversion kinetically at the transition midpoint. Thus, the Z-form by TG repeats has advantages as a torsion buffer and bubble selector while the Z-form by CG repeats likely behaves as torsion absorber. Our statistical physics model supports quantitatively the populations of Z-DNA and reveals the pivotal roles of bubbles in state dynamics. All taken together, a quantitative picture for the transition was deduced within the close interplay among bubbles, plectonemes and Z-DNA.-
dc.description.uri1-
dc.language영어-
dc.publisherOXFORD UNIV PRESS-
dc.titleSequence-dependent cost for Z-form shapes the torsion-driven B-Z transition via close interplay of Z-DNA and DNA bubble-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000649006000010-
dc.identifier.scopusid2-s2.0-85105689758-
dc.identifier.rimsid75700-
dc.contributor.affiliatedAuthorSook Ho Kim-
dc.contributor.affiliatedAuthorHae Jun Jung-
dc.contributor.affiliatedAuthorIl-Buem Lee-
dc.contributor.affiliatedAuthorSeok-Cheol Hong-
dc.identifier.doi10.1093/nar/gkab153-
dc.identifier.bibliographicCitationNUCLEIC ACIDS RESEARCH, v.49, no.7, pp.3651 - 3660-
dc.citation.titleNUCLEIC ACIDS RESEARCH-
dc.citation.volume49-
dc.citation.number7-
dc.citation.startPage3651-
dc.citation.endPage3660-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.subject.keywordPlusHANDED Z-DNA-
dc.subject.keywordPlusTO-Z TRANSITION-
dc.subject.keywordPlusTORQUE MEASUREMENTS-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusELASTICITY-
dc.subject.keywordPlusREVEALS-
dc.subject.keywordPlusANTIBODIES-
dc.subject.keywordPlusDYNAMICS-
dc.subject.keywordPlusGENE-
dc.subject.keywordAuthorHANDED Z-DNA-
dc.subject.keywordAuthorTO-Z TRANSITION-
dc.subject.keywordAuthorTORQUE MEASUREMENTS-
dc.subject.keywordAuthorTRANSCRIPTION-
dc.subject.keywordAuthorELASTICITY-
dc.subject.keywordAuthorREVEALS-
dc.subject.keywordAuthorANTIBODIES-
dc.subject.keywordAuthorDYNAMICS-
dc.subject.keywordAuthorGENE-
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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