BROWSE

Related Scientist

Kim, Do-Kyun's photo.

Kim, Do-Kyun
단백질 커뮤니케이션 그룹
more info

ITEM VIEW & DOWNLOAD

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Cited 0 time in webofscience Cited 0 time in scopus
19 Viewed 0 Downloaded
Title
Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation
Author(s)
Kim, Do-Kyun; Bandara, Geethani; Cho, Young-Eun; Komarow, Hirsh D.; Donahue, Danielle R.; Karim, Baktiar; Baek, Moon-Chang; Kim, Ho Min; Metcalfe, Dean D.; Olivera, Ana
Subject
MAST-CELL LINE, ; EXOSOMAL MIRNAS, ; OSTEOPOROSIS, ; OSTEOCLASTOGENESIS, ; DIFFERENTIATION, ; PATHOGENESIS, ; REGULATORS, ; DISEASES
Publication Date
2021-05-05
Journal
NATURE COMMUNICATIONS, v.12, no.1, pp.1 - 18
Publisher
NATURE RESEARCH
Abstract
Osteoporosis and other manifestations of bone disease are frequent in patients with systemic mastocytosis (SM) in association with the presence of mast cell infiltrates in bone marrow, although the mechanisms behind bone disease remain poorly understood. We find that extracellular vesicles (EVs) released by neoplastic mast cells and present in the serum of patients with SM (SM-EVs) block osteoblast differentiation and mineralization in culture, and when injected into mice diminish the expression of osteoblast markers, and trabecular bone volume and microarchitecture. We demonstrate that miRNA-30a and miRNA-23a, increased in SM-EVs and neoplastic mast cell-derived EVs, attenuate osteoblast maturation by suppressing expression of RUNX2 and SMAD1/5, essential drivers of osteogenesis. Thus, SM-EVs carry and deliver miRNAs that epigenetically interfere with bone formation and can contribute to bone mass reduction in SM. These findings also suggest possibilities for novel approaches to the management of bone disease in mast cell proliferative disorders. Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected into mice, via a mechanism involving suppression of osteogenic factors via miRNA-30a and miRNA-23a.
URI
https://pr.ibs.re.kr/handle/8788114/9774
DOI
10.1038/s41467-021-22754-4
ISSN
2041-1723
Appears in Collections:
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse