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Kim, Do-Kyun
단백질 커뮤니케이션 그룹
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Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

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dc.contributor.authorKim, Do-Kyun-
dc.contributor.authorBandara, Geethani-
dc.contributor.authorCho, Young-Eun-
dc.contributor.authorKomarow, Hirsh D.-
dc.contributor.authorDonahue, Danielle R.-
dc.contributor.authorKarim, Baktiar-
dc.contributor.authorBaek, Moon-Chang-
dc.contributor.authorKim, Ho Min-
dc.contributor.authorMetcalfe, Dean D.-
dc.contributor.authorOlivera, Ana-
dc.date.accessioned2021-06-14T01:30:02Z-
dc.date.accessioned2021-06-14T01:30:02Z-
dc.date.available2021-06-14T01:30:02Z-
dc.date.available2021-06-14T01:30:02Z-
dc.date.created2021-05-27-
dc.date.issued2021-05-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9774-
dc.description.abstractOsteoporosis and other manifestations of bone disease are frequent in patients with systemic mastocytosis (SM) in association with the presence of mast cell infiltrates in bone marrow, although the mechanisms behind bone disease remain poorly understood. We find that extracellular vesicles (EVs) released by neoplastic mast cells and present in the serum of patients with SM (SM-EVs) block osteoblast differentiation and mineralization in culture, and when injected into mice diminish the expression of osteoblast markers, and trabecular bone volume and microarchitecture. We demonstrate that miRNA-30a and miRNA-23a, increased in SM-EVs and neoplastic mast cell-derived EVs, attenuate osteoblast maturation by suppressing expression of RUNX2 and SMAD1/5, essential drivers of osteogenesis. Thus, SM-EVs carry and deliver miRNAs that epigenetically interfere with bone formation and can contribute to bone mass reduction in SM. These findings also suggest possibilities for novel approaches to the management of bone disease in mast cell proliferative disorders. Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected into mice, via a mechanism involving suppression of osteogenic factors via miRNA-30a and miRNA-23a.-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE RESEARCH-
dc.titleMastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000656478200005-
dc.identifier.scopusid2-s2.0-85105408955-
dc.identifier.rimsid75709-
dc.contributor.affiliatedAuthorKim, Do-Kyun-
dc.contributor.affiliatedAuthorKim, Ho Min-
dc.identifier.doi10.1038/s41467-021-22754-4-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.12, no.1, pp.1 - 18-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage18-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusREGULATORS-
dc.subject.keywordPlusDISEASES-
dc.subject.keywordPlusOSTEOPOROSIS-
dc.subject.keywordPlusOSTEOCLASTOGENESIS-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusMAST-CELL LINE-
dc.subject.keywordPlusEXOSOMAL MIRNAS-
dc.subject.keywordAuthorMAST-CELL LINE-
dc.subject.keywordAuthorEXOSOMAL MIRNAS-
dc.subject.keywordAuthorOSTEOPOROSIS-
dc.subject.keywordAuthorOSTEOCLASTOGENESIS-
dc.subject.keywordAuthorDIFFERENTIATION-
dc.subject.keywordAuthorPATHOGENESIS-
dc.subject.keywordAuthorREGULATORS-
dc.subject.keywordAuthorDISEASES-
Appears in Collections:
Pioneer Research Center for Biomolecular and Cellular Structure(바이오분자 및 세포구조 연구단) > Protein Communication Group(단백질 커뮤니케이션 그룹) > 1. Journal Papers (저널논문)
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