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나노의학 연구단
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Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury

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dc.contributor.authorYoonhee Jin-
dc.contributor.authorDena Shahriari-
dc.contributor.authorEun Je Jeon-
dc.contributor.authorSeongjun Park-
dc.contributor.authorYi Sun Choi-
dc.contributor.authorJonghyeok Back-
dc.contributor.authorHyungsuk Lee-
dc.contributor.authorPolina Anikeeva-
dc.contributor.authorSeung-Woo Cho-
dc.date.accessioned2021-04-13T04:50:00Z-
dc.date.accessioned2021-04-13T04:50:00Z-
dc.date.available2021-04-13T04:50:00Z-
dc.date.available2021-04-13T04:50:00Z-
dc.date.created2021-03-11-
dc.date.issued2021-04-
dc.identifier.issn0935-9648-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9455-
dc.description.abstractSkeletal muscle has an inherent capacity for spontaneous regeneration. However, recovery after severe injuries such as volumetric muscle loss (VML) is limited. There is therefore a need to develop interventions to induce functional skeletal muscle restoration. One suggested approach includes tissue-engineered muscle constructs. Tissue-engineering treatments have so far been impeded by the lack of reliable cell sources and the challenges in engineering of suitable tissue scaffolds. To address these challenges, muscle extracellular matrix (MEM) and induced skeletal myogenic progenitor cells (iMPCs) are integrated within thermally drawn fiber based microchannel scaffolds. The microchannel fibers decorated with MEM enhance differentiation and maturation of iMPCs. Furthermore, engraftment of these bioengineered hybrid muscle constructs induce de novo muscle regeneration accompanied with microvessel and neuromuscular junction formation in a VML mouse model, ultimately leading to functional recovery of muscle activity.-
dc.description.uri1-
dc.language영어-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleFunctional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000619416600001-
dc.identifier.scopusid2-s2.0-85101050671-
dc.identifier.rimsid75051-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1002/adma.202007946-
dc.identifier.bibliographicCitationADVANCED MATERIALS, v.33, no.14-
dc.citation.titleADVANCED MATERIALS-
dc.citation.volume33-
dc.citation.number14-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordAuthordirect reprogramming-
dc.subject.keywordAuthorskeletal muscle regeneration-
dc.subject.keywordAuthorthermal fiber drawing-
dc.subject.keywordAuthorvolumetric muscle loss-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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