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Regulation of microRNA biogenesis Highly Cited Paper

Cited 1356 time in webofscience Cited 0 time in scopus
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Title
Regulation of microRNA biogenesis
Author(s)
Minju Ha; Kim , Vic Narry
Publication Date
2014-08
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY, v.15, no.8, pp.509 - 524
Publisher
NATURE PUBLISHING GROUP
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ~22 nucleotides in length, and they are produced by two RNase III proteins — Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging.
URI
https://pr.ibs.re.kr/handle/8788114/945
ISSN
1471-0072
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
RNA 25_Nature Reviews.pdfDownload

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