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Role of Blimp-1 in programing Th effector cells into IL-10 producers

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dc.contributor.authorNeumann, C-
dc.contributor.authorHeinrich, F-
dc.contributor.authorNeumann, K-
dc.contributor.authorJunghans, V-
dc.contributor.authorMashreghi, MF-
dc.contributor.authorAhlers, J-
dc.contributor.authorJanke, M-
dc.contributor.authorRudolph, C-
dc.contributor.authorMockel-Tenbrinck, N-
dc.contributor.authorKuhl, AA-
dc.contributor.authorHeimesaat, MM-
dc.contributor.authorEsser, C-
dc.contributor.authorSin Hyeog Im-
dc.contributor.authorRadbruch, A-
dc.contributor.authorRutz, S-
dc.contributor.authorScheffold, A-
dc.date.available2015-04-20T05:34:37Z-
dc.date.created2014-11-12ko
dc.date.issued2014-08-
dc.identifier.issn0022-1007-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/933-
dc.description.abstractSecretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the transcriptional regulation of IL-10 expression in proinflammatory T helper (Th) 1 cells is insufficiently understood. We report a crucial role for the transcriptional regulator Blimp-1, induced by IL-12 in a STAT4-dependent manner, in controlling IL-10 expression in Th1 cells. Blimp-1 deficiency led to excessive inflammation during Toxoplasma gondii infection with increased mortality. IL-10 production from Th1 cells was strictly dependent on Blimp-1 but was further enhanced by the synergistic function of c-Maf, a transcriptional regulator of IL-10 induced by multiple factors, such as the Notch pathway. We found Blimp-1 expression, which was also broadly induced by IL-27 in effector T cells, to be antagonized by transforming growth factor (TGF) . While effectively blocking IL-10 production from Th1 cells, TGF- shifted IL-10 regulation from a Blimp-1–dependent to a Blimp-1–independent pathway in IL-27– induced Tr1 (T regulatory 1) cells. Our findings further illustrate how IL-10 regulation in Th cells relies on several transcriptional programs that integrate various signals from the environment to fine-tune expression of this critical immunosuppressive cytokine.-
dc.description.uri1-
dc.language영어-
dc.publisherROCKEFELLER UNIV PRESS-
dc.subjectAhR, arylhydrocarbon receptor-
dc.subjectCBA, cytometric bead array-
dc.subjectChIP,chromatin immunoprecipitation, CNS, conserved noncoding sequence-
dc.titleRole of Blimp-1 in programing Th effector cells into IL-10 producers-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000342744500011-
dc.identifier.scopusid2-s2.0-84906534462-
dc.identifier.rimsid16397ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorSin Hyeog Im-
dc.identifier.doi10.1084/jem.20131548-
dc.identifier.bibliographicCitationJOURNAL OF EXPERIMENTAL MEDICINE, v.211, no.9, pp.1807 - 1819-
dc.citation.titleJOURNAL OF EXPERIMENTAL MEDICINE-
dc.citation.volume211-
dc.citation.number9-
dc.citation.startPage1807-
dc.citation.endPage1819-
dc.date.scptcdate2018-10-01-
dc.description.wostc49-
dc.description.scptc48-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusFACTOR C-MAF-
dc.subject.keywordPlusTRANSCRIPTIONAL REPRESSOR BLIMP-1-
dc.subject.keywordPlusCUTTING EDGE-
dc.subject.keywordPlusTOXOPLASMA-GONDII-
dc.subject.keywordPlusCD154 EXPRESSION-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusT(H)17 CELLS-
dc.subject.keywordPlusIL-27-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusINTERLEUKIN-10-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > 1. Journal Papers (저널논문)
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