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Byung Gyu, Kim
유전체 항상성 연구단
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Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity

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Title
Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity
Author(s)
Goughnour, Peter C.; Park, Min Chul; Kim, Sang Bum; Jun, Sangmi; Yang, Won Suk; Chae, Sehyun; Cho, Seongmin; Song, Chihong; Lee, Ji-Hyun; Hyun, Jae Kyung; Kim, Byung Gyu; Hwang, Daehee; Jung, Hyun Suk; Gho, Yong Song; Kim, Sunghoon
Publication Date
2020-11
Journal
Journal of Extracellular Vesicles, v.10, no.1
Publisher
John Wiley and Sons Inc
Abstract
Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular VesiclesGlycyl-tRNA synthetase 1 (GARS1), a cytosolic enzyme secreted from macrophages, promotes apoptosis in cancer cells. However, the mechanism underlying GARS1 secretion has not been elucidated. Here, we report that GARS1 is secreted through unique extracellular vesicles (EVs) with a hydrodynamic diameter of 20–58 nm (mean diameter: 36.9 nm) and a buoyant density of 1.13–1.17 g/ml. GARS1 was anchored to the surface of these EVs through palmitoylated C390 residue. Proteomic analysis identified 164 proteins that were uniquely enriched in the GARS1-containing EVs (GARS1-EVs). Among the identified factors, insulin-like growth factor II receptor, and vimentin also contributed to the anti-cancer activity of GARS1-EVs. This study identified the unique secretory vesicles containing GARS1 and various intracellular factors that are involved in the immunological defence response against tumorigenesis.
URI
https://pr.ibs.re.kr/handle/8788114/9244
DOI
10.1002/jev2.12029
ISSN
2001-3078
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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