BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus

Cited 0 time in webofscience Cited 0 time in scopus
30 Viewed 0 Downloaded
Title
Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
Author(s)
Soyoun Kim; Jung, Dajung; Royer, Sebastien
Publication Date
2020-09
Journal
NATURE COMMUNICATIONS, v.11, no.1, pp.1 - 15
Publisher
NATURE RESEARCH
Abstract
Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days as mice repetitively run through a sequence of objects fixed onto a treadmill belt. We observe a progressive transformation of GC spatial representations, from a sparse encoding of object locations and spatial patterns to increasingly more single, evenly dispersed place fields, while MCs show little transformation and preferentially encode object locations. A competitive learning model of the DG reproduces GC transformations via the progressive integration of landmark-vector cells and spatial inputs and requires MC-mediated feedforward inhibition to evenly distribute GC representations, suggesting that GCs slowly encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations.
URI
https://pr.ibs.re.kr/handle/8788114/9157
DOI
10.1038/s41467-020-18351-6
ISSN
2041-1723
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse