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Lee, Hyuek Jong
혈관 연구단
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VEGFR2 signaling drives meningeal vascular regeneration upon head injury

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Title
VEGFR2 signaling drives meningeal vascular regeneration upon head injury
Author(s)
Koh, B.I.; Hyuek Jong Lee; Pil Ae Kwak; Myung Jin Yang; Kim, J.-H.; Kim, H.-S.; Gou Young Koh; Kim, I.
Publication Date
2020-07
Journal
Nature Communications, v.11, no.1, pp.1 - 17
Publisher
Nature Publishing Group
Abstract
Upon severe head injury (HI), blood vessels of the meninges and brain parenchyma are inevitably damaged. While limited vascular regeneration of the injured brain has been studied extensively, our understanding of meningeal vascular regeneration following head injury is quite limited. Here, we identify key pathways governing meningeal vascular regeneration following HI. Rapid and complete vascular regeneration in the meninges is predominantly driven by VEGFR2 signaling. Substantial increase of VEGFR2 is observed in both human patients and mouse models of HI, and endothelial cell-specific deletion of Vegfr2 in the latter inhibits meningeal vascular regeneration. We further identify the facilitating, stabilizing and arresting roles of Tie2, PDGFRβ and Dll4 signaling, respectively, in meningeal vascular regeneration. Prolonged inhibition of this angiogenic process following HI compromises immunological and stromal integrity of the injured meninges. These findings establish a molecular framework for meningeal vascular regeneration after HI, and may guide development of wound healing therapeutics
URI
https://pr.ibs.re.kr/handle/8788114/9033
DOI
10.1038/s41467-020-17545-2
ISSN
2041-1723
Appears in Collections:
Center for Vascular Research(혈관 연구단) > 1. Journal Papers (저널논문)
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