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Heo, Won Do
인지 및 사회성 연구단
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Optogenetic tools for dissecting complex intracellular signaling pathways

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Title
Optogenetic tools for dissecting complex intracellular signaling pathways
Author(s)
Eury Kwon; Won Do Heo
Publication Date
2020-06
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.527, no.2, pp.331 - 336
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
© 2020 Elsevier Inc. All rights reserved. Intracellular signaling forms complicated networks that involve dynamic alterations of the protein-protein interactions occurring inside a cell. To dissect these complex networks, light-inducible optogenetic technologies have offered a novel approach for modulating the function of intracellular machineries in space and time. Optogenetic approaches combine genetic and optical methods to initiate and control protein functions within live cells. In this review, we provide an overview of the optical strategies that can be used to manipulate intracellular signaling proteins and secondary messengers at the molecular level. We briefly address how an optogenetic actuator can be engineered to enhance homo- or hetero-interactions, survey various optical tools and targeting strategies for controlling cell-signaling pathways, examine their extension to in vivo systems and discuss the future prospects for the field
URI
https://pr.ibs.re.kr/handle/8788114/8984
DOI
10.1016/j.bbrc.2019.12.132
ISSN
1090-2104
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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