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Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo

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Title
Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo
Author(s)
Choi, Y; Seongchan Kim; Myung-Ho Choi; Soo-Ryoon Ryoo; Park, J; Dal-Hee Min; Kim, BS
Publication Date
2014-10
Journal
ADVANCED FUNCTIONAL MATERIALS, v.24, no.37, pp.5781 - 5789
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Photosensitizers (PSs) are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for targeted photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, a novel design is described of highly biocompatible, fl uorescent, folic acid (FA)-functionalized carbon nanodots (CDs) as carriers for the PS zinc phthalocyanine (ZnPc) to achieve simultaneous biological imaging and targeted photodynamic therapy. FA is modifi ed on PEG- passivated CDs (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is loaded onto CD-PEG-FA via π–π stacking interactions. CD-PEG-FA/ZnPc exhibits excellent targeted delivery of the PS, leading to simultaneous imaging and signifi cant targeted photodynamic therapy after irradiation in vitro and in vivo. The present CD-based targeted delivery of PSs is anticipated to offer a convenient and effective platform for enhanced photodynamic therapy to treat cancers in the near future.
URI
https://pr.ibs.re.kr/handle/8788114/887
ISSN
1616-301X
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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