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Lee, Hyun Ji
유전체 교정 연구단
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Genome editing methods in animal models

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Title
Genome editing methods in animal models
Author(s)
Hyunji Lee; Da Eun Yoon; Kyoungmi Kim
Publication Date
2020-02
Journal
ANIMAL CELLS AND SYSTEMS, v.24, no.1, pp.8 - 16
Publisher
TAYLOR & FRANCIS LTD
Abstract
© 2020 The Author(s). Genetically engineered animal models that reproduce human diseases are very important for the pathological study of various conditions. The development of the clustered regularly interspaced short palindromic repeats (CRISPR) system has enabled a faster and cheaper production of animal models compared with traditional gene-targeting methods using embryonic stem cells. Genome editing tools based on the CRISPR-Cas9 system are a breakthrough technology that allows the precise introduction of mutations at the target DNA sequences. In particular, this accelerated the creation of animal models, and greatly contributed to the research that utilized them. In this review, we introduce various strategies based on the CRISPR-Cas9 system for building animal models of human diseases and describe various in vivo delivery methods of CRISPR-Cas9 that are applied to disease models for therapeutic purposes. In addition, we summarize the currently available animal models of human diseases that were generated using the CRISPR-Cas9 system and discuss future directions
URI
https://pr.ibs.re.kr/handle/8788114/8732
DOI
10.1080/19768354.2020.1726462
ISSN
1976-8354
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > 1. Journal Papers (저널논문)
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