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Intrinsic Peroxidase-Mimicking Ir Nanoplates for Nanozymatic Anticancer and Antibacterial Treatment

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Title
Intrinsic Peroxidase-Mimicking Ir Nanoplates for Nanozymatic Anticancer and Antibacterial Treatment
Author(s)
Yim, G; Kim, CY; Seounghun Kang; Dal-Hee Min; Kang, K; Jang, H
Subject
antibacterial, ; anticancer, ; iridium nanoplates, ; nanozyme, ; peroxidase
Publication Date
2020-09
Journal
ACS APPLIED MATERIALS & INTERFACES, v.12, no.37, pp.41062 - 41070
Publisher
AMER CHEMICAL SOC
Abstract
© 2020 American Chemical Society. The study of inorganic nanozymes to overcome the disadvantages of bio-enzymes, such as the requirement of optimized reaction conditions and lack of durability against environmental factors, is one of the most significant research topics at present. In this work, we comprehensively analyzed the intrinsic peroxidase-like activity of Ir-based nanoparticles, the biological and nanozymatic potentials of which have not yet been explored. These particles were synthesized by the galvanic replacement of Ag nanoplates with Ir. Through the confirmed peroxidase-like activity and hydrogen peroxide decomposition with free radical generation facilitated by these particles, the antibacterial and anticancer effects were successfully verified in vitro. The nanozyme-based therapeutic effect observed at concentrations at which these nanoparticles do not show cytotoxicity suggests that it is possible to achieve more precise and selective local treatment with these particles. The observed highly efficient peroxidase-like activity of these nanoparticles is attributed to the partially mixed composition of Ir-Ag-IrO2 formed through the galvanic replacement reaction in the synthetic process
URI
https://pr.ibs.re.kr/handle/8788114/8484
DOI
10.1021/acsami.0c10981
ISSN
1944-8244
Appears in Collections:
Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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