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Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning

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Title
Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning
Author(s)
Yera Choi; Emily Yunha Shin; Sungshin Kim
Subject
Caudate nucleus, ; Cortico-caudate interactions, ; De novo motor skill learning, ; FMRI, ; Spatiotemporal dissociation
Publication Date
2020-09
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.38, pp.23886 - 23897
Publisher
NATL ACAD SCIENCES
Abstract
© 2020 National Academy of Sciences. Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goaldirected and later automatic stages of motor skill learning, respectively. However, the involvement of these circuits has not been well elucidated in human de novo motor skill learning, which requires learning arbitrary action-outcome associations and valuebased action selection. To investigate this issue, we conducted a human functional MRI (fMRI) experiment in which participants learned to control a computer cursor by manipulating their right fingers. We discovered a double dissociation of fMRI activity in the anterior and posterior caudate nucleus, which was associated with performance in the early and late learning stages. Moreover, cognitive and sensorimotor cortico-caudate interactions predicted individual learning performance. Our results suggest parallel corticocaudate networks operating in different stages of human de novo motor skill learning
URI
https://pr.ibs.re.kr/handle/8788114/8480
DOI
10.1073/pnas.2003963117
ISSN
0027-8424
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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