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Direct visualization and characterization of the human zona incerta and surrounding structures

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Title
Direct visualization and characterization of the human zona incerta and surrounding structures
Author(s)
Jonathan C. Lau; Yiming Xiao; Roy A. M. Haast; Greydon Gilmore; Kâmil Uludag; Keith W. MacDougall; Ravi S. Menon; Andrew G. Parrent; Terry M. Peters; Ali R. Khan
Subject
7 T, ; atlas, ; brain, ; deep brain stimulation, ; human, ; neuroanatomy, ; quantitative MRI, ; T1, ; zona incerta
Publication Date
2020-11
Journal
HUMAN BRAIN MAPPING, v.41, no.16, pp.4500 - 4517
Publisher
WILEY-BLACKWELL
Abstract
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. The zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 T) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields of Forel (fasciculus lenticularis, fasciculus thalamicus, and field H), and medial lemniscus. Using this approach, we successfully derived in vivo estimates of the size, shape, location, and tissue characteristics of substructures in the ZI region, confirming observations only previously possible through histological evaluation that this region is not just a space between structures but contains distinct morphological entities that should be considered separately. Our findings pave the way for increasingly detailed in vivo study and provide a structural foundation for precise functional and neuromodulatory investigation
URI
https://pr.ibs.re.kr/handle/8788114/8450
DOI
10.1002/hbm.25137
ISSN
1065-9471
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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