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The tumor–fat interface volume of breast cancer on pretreatment mri is associated with a pathologic response to neoadjuvant chemotherapy

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Title
The tumor–fat interface volume of breast cancer on pretreatment mri is associated with a pathologic response to neoadjuvant chemotherapy
Author(s)
Hwan-ho Cho; Minsu Park; Hyunjin Park; Eun Sook Ko; Na Young Hwang; Young-Hyuck Im; Kyounglan Ko; Sung Hoon Sim
Subject
Adipose tissue, ; Breast cancer, ; MRI, ; Neoadjuvant chemotherapy, ; Pathological complete response
Publication Date
2020-11
Journal
BIOLOGY, v.9, no.11, pp.391
Publisher
MDPI AG
Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adipocytes are active sources of numerous adipokines that work in both a paracrine and endocrine manner. It is not known that the direct contact between tumor and neighboring fat measured by pretreatment breast magnetic resonance imaging (MRI) affects treatment outcomes to neoadjuvant chemotherapy (NAC) in breast cancer patients. A biomarker quantifying the tumor–fat interface volume from pretreatment MRI was proposed and used to predict pathologic complete response (pCR) in breast cancer patients treated with NAC. The tumor–fat interface volume was computed with data-driven clustering using multiphasic MRI. Our approach was developed and validated in two cohorts consisting of 1140 patients. A high tumor–fat interface volume was significantly associated with a non-pCR in both the development and validation cohorts (p = 0.030 and p = 0.037, respectively). Quantitative measurement of the tumor–fat interface volume based on pretreatment MRI may be useful for precision medicine and subsequently influence the treatment strategy of patients
URI
https://pr.ibs.re.kr/handle/8788114/8447
DOI
10.3390/biology9110391
ISSN
2079-7737
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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