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Prediction of age at onset in Parkinson’s disease using objective specific neuroimaging genetics based on a sparse canonical correlation analysis

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Title
Prediction of age at onset in Parkinson’s disease using objective specific neuroimaging genetics based on a sparse canonical correlation analysis
Author(s)
Ji Hye Won; Mansu Kim; Jinyoung Youn; Hyunjin Park
Subject
GENOME-WIDE ASSOCIATION, ; DRUG-NAIVE PATIENTS, ; QUALITY-OF-LIFE, ; NONMOTOR SYMPTOMS, ; CLINICAL-FEATURES, ; RISK, ; DIAGNOSIS, ; PATTERNS, ; IMPACT, ; CORTEX
Publication Date
2020-12
Journal
SCIENTIFIC REPORTS, v.10, no.1, pp.11662
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2020, The Author(s). The age at onset (AAO) is an important determinant in Parkinson’s disease (PD). Neuroimaging genetics is suitable for studying AAO in PD as it jointly analyzes imaging and genetics. We aimed to identify features associated with AAO in PD by applying the objective-specific neuroimaging genetics approach and constructing an AAO prediction model. Our objective-specific neuroimaging genetics extended the sparse canonical correlation analysis by an additional data type related to the target task to investigate possible associations of the imaging–genetic, genetic–target, and imaging–target pairs simultaneously. The identified imaging, genetic, and combined features were used to construct analytical models to predict the AAO in a nested five-fold cross-validation. We compared our approach with those from two feature selection approaches where only associations of imaging–target and genetic–target were explored. Using only imaging features, AAO prediction was accurate in all methods. Using only genetic features, the results from other methods were worse or unstable compared to our model. Using both imaging and genetic features, our proposed model predicted the AAO well (r = 0.5486). Our findings could have significant impacts on the characterization of prodromal PD and contribute to diagnosing PD early because genetic features could be measured accurately from birth
URI
https://pr.ibs.re.kr/handle/8788114/8441
DOI
10.1038/s41598-020-68301-x
ISSN
2045-2322
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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