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Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation

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Title
Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation
Author(s)
Hee Ho Park; Wooram Park; Yun Young Lee; Hyelim Kim; Hee Seung Seo; Dong Wook Choi; Ho-Keun Kwon; Dong Hee Na; Tae-Hyung Kim; Young Bin Choy; June Hong Ahn; Wonhwa Lee; Chun Gwon Park
Subject
Bioinspiration, ; COVID-19, ; DNase-I, ; Nanospheres, ; NETosis
Publication Date
2020-12
Journal
ADVANCED SCIENCE, v.7, no.23, pp.2001940
Publisher
WILEY-VCH GmbH
Abstract
© 2020 The Authors. Published by Wiley-VCH GmbHThe current outbreak of the beta-coronavirus (beta-Cov) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019. No specific antiviral treatments or vaccines are currently available. A recent study has reported that coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with neutrophil-specific plasma membrane rupture, and release excessive neutrophil extracellular traps (NETs) and extracellular DNAs (eDNAs). This mechanism involves the activation of NETosis, a neutrophil-specific programmed cell death, which is believed to play a crucial role in COVID-19 pathogenesis. Further progression of the disease can cause uncontrolled inflammation, leading to the initiation of cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. Herein, it is reported that DNase-I-coated melanin-like nanospheres (DNase-I pMNSs) mitigate sepsis-associated NETosis dysregulation, thereby preventing further progression of the disease. Recombinant DNase-I and poly(ethylene glycol) (PEG) are used as coatings to promote the lengthy circulation and dissolution of NET structure. The data indicate that the application of bioinspired DNase-I pMNSs reduce neutrophil counts and NETosis-related factors in the plasma of SARS-CoV-2 sepsis patients, alleviates systemic inflammation, and attenuates mortality in a septic mouse model. Altogether, the findings suggest that these nanoparticles have potential applications in the treatment of SARS-CoV-2-related illnesses and other beta-CoV-related diseases
URI
https://pr.ibs.re.kr/handle/8788114/8438
DOI
10.1002/advs.202001940
ISSN
2198-3844
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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