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Unraveling the contributions to the neuromelanin-MRI contrast

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Title
Unraveling the contributions to the neuromelanin-MRI contrast
Author(s)
Nikos Priovoulos; Stan C. J. van Boxel; Heidi I. L. Jacobs; Benedikt A. Poser; Kamil Uludag; Frans R. J. Verhey; Dimo Ivanov
Subject
Locus coeruleus, ; Magnetization transfer, ; Neuromelanin, ; Neuromelanin-MRI, ; Substantia nigra
Publication Date
2020-12
Journal
Brain Structure & Function, v.225, no.9, pp.2757 - 2774
Publisher
SPRINGER HEIDELBERG
Abstract
© 2020, The Author(s). The Locus Coeruleus (LC) and the Substantia Nigra (SN) are small brainstem nuclei that change with aging and may be involved in the development of various neurodegenerative and psychiatric diseases. Magnetization Transfer (MT) MRI has been shown to facilitate LC and the SN visualization, and the observed contrast is assumed to be related to neuromelanin accumulation. Imaging these nuclei may have predictive value for the progression of various diseases, but interpretation of previous studies is hindered by the fact that the precise biological source of the contrast remains unclear, though several hypotheses have been put forward. To inform clinical studies on the possible biological interpretation of the LC- and SN contrast, we examined an agar-based phantom containing samples of natural Sepia melanin and synthetic Cys-Dopa-Melanin and compared this to the in vivo human LC and SN. T1 and T2* maps, MT spectra and relaxation times of the phantom, the LC and the SN were measured, and a two-pool MT model was fitted. Additionally, Bloch simulations and a transient MT experiment were conducted to confirm the findings. Overall, our results indicate that Neuromelanin-MRI contrast in the LC likely results from a lower macromolecular fraction, thus facilitating interpretation of results in clinical populations. We further demonstrate that in older individuals T1 lengthening occurs in the LC
URI
https://pr.ibs.re.kr/handle/8788114/8436
DOI
10.1007/s00429-020-02153-z
ISSN
1863-2653
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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