BROWSE

Related Scientist

CNIR's photo.

CNIR
뇌과학 이미징 연구단
more info

ITEM VIEW & DOWNLOAD

Effects of MP2RAGE B-1(+) sensitivity on inter-site T-1 reproducibility and hippocampal morphometry at 7T

Cited 0 time in webofscience Cited 0 time in scopus
19 Viewed 0 Downloaded
Title
Effects of MP2RAGE B-1(+) sensitivity on inter-site T-1 reproducibility and hippocampal morphometry at 7T
Author(s)
Roy A.M. Haast; Jonathan C. Lau; Dimo Ivanov; Ravi S. Menon; Kâmil Uludağ; Ali R. Khan
Subject
HUMAN BRAIN, ; PROBABILISTIC ATLAS, ; RELAXATION-TIMES, ; STEADY-STATE, ; SEGMENTATION, ; MRI, ; RESOLUTION, ; INVERSION, ; FRAMEWORK, ; BIOMARKER
Publication Date
2021-01-01
Journal
NEUROIMAGE, v.224, pp.117373
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Abstract
Most neuroanatomical studies are based on T-1-weighted MR images, whose intensity profiles are not solely determined by the tissue's longitudinal relaxation times (T-1), but also affected by varying non-T-1 contributions, hampering data reproducibility. In contrast, quantitative imaging using the MP2RAGE sequence, for example, allows direct characterization of the brain based on the tissue property of interest. Combined with 7 Tesla (7T) MRI, this offers unique opportunities to obtain robust high-resolution brain data characterized by a high reproducibility, sensitivity and specificity. However, specific MP2RAGE parameter choices - e.g., to emphasize intracortical myelin-dependent contrast variations - can substantially impact image quality and cortical analyses through remnants of B-1(+)-related intensity variations, as illustrated in our previous work. To follow up on this: we (1) validate this protocol effect using a dataset acquired with a particularly B-1(+) insensitive set of MP2RAGE parameters combined with parallel transmission excitation; and (2) extend our analyses to evaluate the effects on hippocampal morphometry. The latter remained unexplored initially, but can provide important insights related to generalizability and reproducibility of neurodegenerative research using 7T MRI. We confirm that B-1(+) inhomogeneities have a considerably variable effect on cortical T-1 estimates, as well as on hippocampal morphometry depending on the MP2RAGE setup. While T-1 differed substantially across datasets initially, we show the inter-site T-1 comparability improves after correcting for the spatially varying B-1(+) field using a separately acquired Sa2RAGE B-1(+) map. Finally, removal of B-1(+) residuals affects hippocampal volumetry and boundary definitions, particularly near structures characterized by strong intensity changes (e.g. cerebral spinal fluid). Taken together, we show that the choice of MP2RAGE parameters can impact T-1 comparability across sites and present evidence that hippocampal segmentation results are modulated by B-1(+) inhomogeneities. This calls for careful (1) consideration of sequence parameters when setting acquisition protocols, as well as (2) acquisition of a B-1(+) map to correct MP2RAGE data for potential B-1(+) variations to allow comparison across datasets.
URI
https://pr.ibs.re.kr/handle/8788114/8426
DOI
10.1016/j.neuroimage.2020.117373
ISSN
1053-8119
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse