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Hahm, Jeong Hoon
식물 노화·수명 연구단
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A cellular surveillance and defense system that delays aging phenotypes in C. elegans

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Title
A cellular surveillance and defense system that delays aging phenotypes in C. elegans
Author(s)
Jeong-Hoon Hahm; ChoLong Jeong; Wonhee Lee; Hee Jung Koo; Sunhee Kim; Daehee Hwang; Hong Gil Nam
Subject
Aging, ; C. elegans, ; Compensation, ; Mitochondria, ; ZIP-2
Publication Date
2020-05
Journal
Aging-US, v.12, no.9, pp.8202 - 8220
Publisher
IMPACT JOURNALS LLCUS Administration on Aging
Abstract
© Hahm et al.Physiological stresses, such as pathogen infection, are detected by "cellular Surveillance Activated Detoxification and Defenses" (cSADD) systems that trigger host defense responses. Aging is associated with physiological stress, including impaired mitochondrial function. Here, we investigated whether an endogenous cSADD pathway is activated during aging in C. elegans. We provide evidence that the transcription factor ZIP-2, a well-known immune response effector in C. elegans, is activated in response to age-associated mitochondrial dysfunction. ZIP-2 mitigates multiple aging phenotypes, including mitochondrial disintegration and reduced motility of the pharynx and intestine. Importantly, our data suggest that ZIP-2 is activated during aging independently of bacterial infection and of the transcription factors ATFS-1 and CEBP-2. Thus, ZIP-2 is a key component of an endogenous pathway that delays aging phenotypes in C. elegans. Our data suggest that aging coopted a compensatory strategy for regulation of aging process as a guarded process rather than a simple passive deterioration process
URI
https://pr.ibs.re.kr/handle/8788114/7872
DOI
10.18632/aging.103134
ISSN
1945-4589
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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