IBS Publications Repository: Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

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Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

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Title: Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

Author(s): Shinae Kwak; Namjung Huh; Ji-seon Seo; Jung-Eun Lee; Pyung-Lim Han; Min Whan Jung

Abstract: Inordertoinvestigaterolesofdopaminereceptorsubtypesinreward-basedlearning,weexaminedchoicebehaviorofdopamineD1andD2receptor-knockout(D1R-KOandD2R-KO,respectively)miceinaninstrumentallearningtaskwithprogressivelyincreasingreversalfrequencyandadynamictwo-armedbandittask.PerformanceofD2R-KOmicewasprogressivelyimpairedintheformerasthefrequencyofreversalincreasedandprofoundlyimpairedinthelatterevenwithprolongedtraining,whereasD1R-KOmiceshowedrelativelyminorperformancedeficits.Choicebehaviorinthedynamictwo-armedbandittaskwaswellexplainedbyahybridmodelincludingwin-stay-lose-switchandreinforcementlearningterms.Amodel-basedanalysisrevealedincreasedwin-stay,butimpairedvalueupdatinganddecreasedvalue-dependentactionselectioninD2R-KOmice,whichweredetrimentaltomaximizingrewardsinthedynamictwo-armedbandittask.TheseresultssuggestanimportantroleofdopamineD2receptorsinlearningfrompastchoiceoutcomesforrapidadjustmentofchoicebehaviorinadynamicanduncertainenvironment.