IBS Publications Repository: Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

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IBS Publications RepositoryCenter for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단)1. Journal Papers (저널논문)

Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

DC Field	Value	Language
dc.contributor.author	Shinae Kwak	-
dc.contributor.author	Namjung Huh	-
dc.contributor.author	Ji-seon Seo	-
dc.contributor.author	Jung-Eun Lee	-
dc.contributor.author	Pyung-Lim Han	-
dc.contributor.author	Min Whan Jung	-
dc.date.available	2015-04-19T10:57:24Z	-
dc.date.created	2015-01-21	-
dc.date.issued	2014-10	-
dc.identifier.issn	1662-5153	-
dc.identifier.uri	https://pr.ibs.re.kr/handle/8788114/770	-
dc.description.abstract	Inordertoinvestigaterolesofdopaminereceptorsubtypesinreward-basedlearning,weexaminedchoicebehaviorofdopamineD1andD2receptor-knockout(D1R-KOandD2R-KO,respectively)miceinaninstrumentallearningtaskwithprogressivelyincreasingreversalfrequencyandadynamictwo-armedbandittask.PerformanceofD2R-KOmicewasprogressivelyimpairedintheformerasthefrequencyofreversalincreasedandprofoundlyimpairedinthelatterevenwithprolongedtraining,whereasD1R-KOmiceshowedrelativelyminorperformancedeficits.Choicebehaviorinthedynamictwo-armedbandittaskwaswellexplainedbyahybridmodelincludingwin-stay-lose-switchandreinforcementlearningterms.Amodel-basedanalysisrevealedincreasedwin-stay,butimpairedvalueupdatinganddecreasedvalue-dependentactionselectioninD2R-KOmice,whichweredetrimentaltomaximizingrewardsinthedynamictwo-armedbandittask.TheseresultssuggestanimportantroleofdopamineD2receptorsinlearningfrompastchoiceoutcomesforrapidadjustmentofchoicebehaviorinadynamicanduncertainenvironment.	-
dc.language	영어	-
dc.publisher	FRONTIERS RES FOUND	-
dc.title	Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment	-
dc.type	Article	-
dc.type.rims	ART	-
dc.identifier.wosid	000347895600001	-
dc.identifier.scopusid	2-s2.0-84908391187	-
dc.identifier.rimsid	17019	ko
dc.date.tcdate	2018-10-01	-
dc.contributor.affiliatedAuthor	Shinae Kwak	-
dc.contributor.affiliatedAuthor	Namjung Huh	-
dc.contributor.affiliatedAuthor	Min Whan Jung	-
dc.identifier.doi	10.3389/fnbeh.2014.00368	-
dc.identifier.bibliographicCitation	FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v.8, pp.368	-
dc.relation.isPartOf	FRONTIERS IN BEHAVIORAL NEUROSCIENCE	-
dc.citation.title	FRONTIERS IN BEHAVIORAL NEUROSCIENCE	-
dc.citation.volume	8	-
dc.citation.startPage	368	-
dc.date.scptcdate	2018-10-01	-
dc.description.wostc	10	-
dc.description.scptc	9	-
dc.description.journalClass	1	-
dc.description.journalClass	1	-
dc.description.isOpenAccess	N	-
dc.description.journalRegisteredClass	scie	-
dc.description.journalRegisteredClass	scopus	-
dc.subject.keywordPlus	DISCRIMINATION REVERSAL TASK	-
dc.subject.keywordPlus	NUCLEUS-ACCUMBENS	-
dc.subject.keywordPlus	DECISION-MAKING	-
dc.subject.keywordPlus	PREFRONTAL CORTEX	-
dc.subject.keywordPlus	MIDBRAIN DOPAMINE	-
dc.subject.keywordPlus	AVERSIVE BEHAVIOR	-
dc.subject.keywordPlus	DISTINCT ROLES	-
dc.subject.keywordPlus	BASAL GANGLIA	-
dc.subject.keywordPlus	D2-LIKE RECEPTORS	-
dc.subject.keywordPlus	STRIATAL NEURONS	-
dc.subject.keywordAuthor	D1 receptor	-
dc.subject.keywordAuthor	D2 receptor	-
dc.subject.keywordAuthor	reversal	-
dc.subject.keywordAuthor	dynamic foraging task	-
dc.subject.keywordAuthor	mouse	-
dc.subject.keywordAuthor	reinforcement learning	-