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Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: Structure-activity relationship

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Title
Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: Structure-activity relationship
Author(s)
Geewoo Nam; Mannkyu Hong; Juri Lee; Hyuck Jin Lee; Yonghwan Ji; Juhye Kang; Mu-Hyun Baik; Mi Hee Lim
Publication Date
2020-10
Journal
CHEMICAL SCIENCE, v.11, no.37, pp.10243 - 10254
Publisher
ROYAL SOC CHEMISTRY
Abstract
© The Royal Society of Chemistry.Amyloid-β (Aβ) accumulation, metal ion dyshomeostasis, oxidative stress, and cholinergic deficit are four major characteristics of Alzheimer's disease (AD). Herein, we report the reactivities of 12 flavonoids against four pathogenic elements of AD: metal-free and metal-bound Aβ, free radicals, and acetylcholinesterase. A series of 12 flavonoids was selected based on the molecular structures that are responsible for multiple reactivities including hydroxyl substitution and transfer of the B ring from C2 to C3. Our experimental and computational studies reveal that the catechol moiety, the hydroxyl groups at C3 and C7, and the position of the B ring are important for instilling multiple functions in flavonoids. We establish a structure-activity relationship of flavonoids that should be useful for designing chemical reagents with multiple reactivities against the pathological factors of AD. This journal i
URI
https://pr.ibs.re.kr/handle/8788114/7601
DOI
10.1039/d0sc02046j
ISSN
2041-6520
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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