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Oh, Chang Kyu
유전체 항상성 연구단
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LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function

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Title
LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function
Author(s)
CHANG-KYU OH; JEONG JUN PARK; MIHYANG HA; HYE JIN HEO; JUNHO KANG; EUN JUNG KWON; JI WAN KANG; YOUNGJOO KIM; JIN MO KANG; SEUNG ZHOO YOON; YEJI KO; DAI SIK KO; YUN HAK KIM
Subject
apoptosis, ; gene expression omnibus, ; LRRC17, ; Ovarian epithelial cancer, ; survival analysis, ; TCGA, ; zebrafish
Publication Date
2020-10
Journal
ANTICANCER RESEARCH, v.40, no.10, pp.5601 - 5609
Publisher
INT INST ANTICANCER RESEARCH
Abstract
© 2020, International Institute of Anticancer Research. BACKGROUND/AIM: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed LRRC17 as a prognostic gene in serous ovarian cancer. MATERIALS AND METHODS: Data were collected from Gene Expression Omnibus (GSE9891, GSE13876, and GSE26712) and The Cancer Genome Atlas (TCGA). We performed survival analyses using C statistics, area under the curve, survival plot with optimal cutoff level, and cox proportional regression. Zebrafish embryos were used as an in vivo model. RESULTS: The prognosis of patients with high LRRC17 expression was poorer than that of patients with low LRRC17 expression. Multivariate regression analysis showed that LRRC17 expression, age, and stage were independently related with survival. Knockdown of lrrc17 reduced survival rate and delayed development in zebrafish embryos. We also found that lrrc17 is important for cell viability by protecting from p53-dependent apoptosis. CONCLUSION: LRRC17 could be a prognostic gene in ovarian cancer as it regulates cancer cell viability through the p53 pathway
URI
https://pr.ibs.re.kr/handle/8788114/7600
DOI
10.21873/anticanres.14573
ISSN
0250-7005
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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