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Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis

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Title
Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis
Author(s)
Choi, SH; Hyeon, DY; Lee, IH; Park, SJ; Han, S; In Chul Lee; Daehee Hwang; Hong Gil Nam
Publication Date
2014-11
Journal
SCIENTIFIC REPORTS, v.4, no., pp.7197 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12) in Arabidopsis cytokinin signaling using wild-type and single, double, and triple deletion mutants of the TFs. Comparative analysis of gene expression profiles obtained from Arabidopsis roots in wild-type and these mutants showed that duplication of ARR TFs systematically extended their transcriptional regulatory structures, leading to enhanced robustness and diversification in functions of target genes, as well as in regulation of cellular networks of target genes. Therefore, our results suggest that duplication of TFs contributes to robustness and diversification in functions of target genes by extending transcriptional regulatory structures.
URI
http://pr.ibs.re.kr/handle/8788114/760
DOI
10.1038/srep07197
ISSN
2045-2322
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
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