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Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons in familiar and novel environments

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Title
Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons in familiar and novel environments
Author(s)
Joonyeup Lee; Chanmee Bae; Doyun Lee; Min Whan Jung
Publication Date
2020-07
Journal
HIPPOCAMPUS, v.30, no.7, pp.693 - 702
Publisher
WILEY
Abstract
© 2020 Wiley Periodicals, Inc. Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tested whether mossy fiber stimulation affects CA3 spatial firing differently between familiar and novel environments. We compared spatial firing of CA3 neurons before and after optogenetic stimulation of mossy fibers in freely behaving mice in a familiar and three sets of novel environments. We found that CA3 neurons are more responsive to mossy fiber stimulation in the novel than familiar environments. However, we failed to obtain evidence for long-lasting effect of mossy fiber stimulation on spatial firing of CA3 neurons in both the familiar and novel environments. Our results provide further evidence against the view that mossy fibers carry teaching signals. © 2020 Wiley Periodicals, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/7195
ISSN
1050-9631
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Cognitive Glioscience Group(인지 교세포과학 그룹) > Journal Papers (저널논문)
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