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혈관 연구단
혈관 연구단
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YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

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Title
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
Author(s)
Sung Yong Choi; Bae H.; Jeong S.-H.; Intae Park; Hyunsoo Cho; Seon Pyo Hong; Lee D.-H.; Choong-kun Lee; Jin-Sung Park; Sang Heon Suh; Jeongwoon Choi; Myung Jin Yang; Jang J.Y.; Onder L.; Moon J.H.; Jeong H.-S.; Adams R.H.; Kim J.-M.; Ludewig B.; Joo-Hye Song; Lim D.-S.; Gou Young Koh
Publication Date
2020-12
Journal
NATURE COMMUNICATIONS, v.11, no.1, pp.519 -
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2020, The Author(s).Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. Selective depletion of YAP/TAZ in FRCs impairs FRC growth and differentiation and compromises the structural organization of LNs, whereas hyperactivation of YAP/TAZ enhances myofibroblastic characteristics of FRCs and aggravates LN fibrosis. Mechanistically, the interaction between YAP/TAZ and p52 promotes chemokine expression that is required for commitment of FRC lineage prior to lymphotoxin-β receptor (LTβR) engagement, whereas LTβR activation suppresses YAP/TAZ activity for FRC maturation. Our findings thus present YAP/TAZ as critical regulators of commitment and maturation of FRCs, and hold promise for better understanding of FRC-mediated pathophysiologic processes
URI
https://pr.ibs.re.kr/handle/8788114/7117
ISSN
2041-1723
Appears in Collections:
Center for Vascular Research(혈관 연구단) > Journal Papers (저널논문)
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