BROWSE

Related Scientist

Researcher

홍성욱
면역 미생물 공생 연구단
more info

Interleukin-2/antibody complex expanding Foxp3 + regulatory T cells exacerbates Th2-mediated allergic airway inflammation

Cited 0 time in webofscience Cited 0 time in scopus
18 Viewed 2 Downloaded
Title
Interleukin-2/antibody complex expanding Foxp3 + regulatory T cells exacerbates Th2-mediated allergic airway inflammation
Author(s)
Sung-Wook Hong; Eunju O; Jun Young Lee; Jaeu Yi; Kyungjin Cho; Juhee Kim; Daeun Kim; Charles D. Surh; Kwang Soon Kim
Publication Date
2019-04
Journal
BMB REPORTS, v.52, no.4, pp.283 - 288
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Abstract
Foxp3+ regulatory CD4+ T (Treg) cells play an essential role in preventing overt immune responses against self and innocuous foreign antigens. Selective expansion of endogenous Treg cells in response to the administration of interleukin (IL)-2/antibody complex, such as the IL-2/JES6-1 complex (IL-2C) in mice, is considered an attractive therapeutic approach to various immune disorders. Here, we investigated the therapeutic potential of IL-2C in allergic airway inflammation models. IL-2C treatment ameliorated Th17-mediated airway inflammation; however, unexpectedly, IL-2C treatment exacerbated Th2-mediated allergic airway inflammation by inducing the selective expansion of Th2 cells and type-2 innate lymphoid cells. We also found that IL-2 signaling is required for the expansion of Th2 cells in lymphoproliferative disease caused by Treg cell depletion. Our data suggest that IL-2C is selectively applicable to the treatment of allergic airway diseases depending on the characteristics of airway inflammation. [BMB Reports 2019; 52(4): 283-288]. ⓒ 2019 by the The Korean Society for Biochemistry and Molecular Biology
URI
https://pr.ibs.re.kr/handle/8788114/6963
ISSN
1976-6696
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
Interleukin2 antibody complex expanding Foxp3(+) regulatory T cells exacerbates Th2 mediated allergic airway inflammation.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse