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분자활성 촉매반응 연구단
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Visible-Light-Induced Remote C(sp3)-H Pyridylation of Sulfonamides and Carboxamides

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Title
Visible-Light-Induced Remote C(sp3)-H Pyridylation of Sulfonamides and Carboxamides
Author(s)
Namhoon Kim; Changseok Lee; Taehwan Kim; Sungwoo Hong
Publication Date
2019-12
Journal
ORGANIC LETTERS, v.21, no.23, pp.9719 - 9723
Publisher
AMER CHEMICAL SOC
Abstract
© 2019 American Chemical Society.Visible-light-induced site-selective C(sp3)-H pyridylation of amides has been accomplished using N-amidopyridinium salts. The N-centered radicals generated by the single-electron reduction of N-amidopyridinium substrates undergo 1,5-hydrogen atom transfer to form alkyl radical intermediates. Excellent C4-selectivity in radical trapping with pyridinium salts is observed for the alkyl radicals to provide δ-pyridyl sulfonamides and γ-pyridyl carboxamides. The utility is demonstrated by offering a practical approach for the late-stage functionalization of complex amide derivatives
URI
https://pr.ibs.re.kr/handle/8788114/6732
ISSN
1523-7060
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > Journal Papers (저널논문)
Files in This Item:
acs.orglett.9b03879.pdfDownload

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