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Dynamic functional connectivity of migraine brain: a resting-state fMRI study

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Title
Dynamic functional connectivity of migraine brain: a resting-state fMRI study
Author(s)
Mi Ji Lee; Bo-yong Park; Soohyun Cho; Hyunjin Park; Sung-Tae Kim; Chin-Sang Chung
Publication Date
2019-12
Journal
PAIN, v.160, no.12, pp.2776 - 2786
Publisher
ELSEVIER SCIENCE BV
Abstract
Abstract Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connectivity analysis. We prospectively recruited 50 patients with migraine and 50 age- and sex-matched controls. All subjects underwent a resting-state functional magnetic resonance imaging. Significant networks were defined in a data-driven fashion from the interictal (.48 hours apart from headache phases) patients and matched controls (interictal data set) and tested to ictal or peri-ictal patients and controls (ictal/peri-ictal data set). Both static and dynamic analyses were used for the between-group comparison. A false discovery rate correction was performed. As a result, the static analysis did not reveal a network which was significant in both interictal and ictal/peri-ictal data sets. Dynamic analysis revealed significant between-group differences in 7 brain networks in the interictal data set, among which a frontoparietal network (controls . patients, P 5 0.0467), 2 brainstem networks (patients . controls, P 5 0.0467 and ,0.001), and a cerebellar network (controls . patients, P 5 0.0408 and ,0.001 in 2 states) remained significant in the ictal/peri-ictal data set. Using these networks, migraine was classified with a sensitivity of 0.70 and specificity of 0.76 in the ictal/peri-ictal data set. In conclusion, the dynamic connectivity analysis revealed more functional networks related to migraine than the conventional static analysis, suggesting a substantial temporal fluctuation in functional characteristics. Our data also revealed migraine-related networks which show significant difference regardless of headache phases between patients and controls. © 2019 International Association for the Study of Pain
URI
https://pr.ibs.re.kr/handle/8788114/6729
ISSN
0304-3959
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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