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Proteasome subunit RPT2a promotes PTGS through repressing RNA quality control in Arabidopsis

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Title
Proteasome subunit RPT2a promotes PTGS through repressing RNA quality control in Arabidopsis
Author(s)
Myung-Hee Kim; Jieun Jeon; Seulbee Lee; Jae Ho Lee; Lei Gao; Byung-Hoon Lee; Jeong Mee Park; Yun Ju Kim; June M. Kwak
Publication Date
2019-12
Journal
NATURE PLANTS, v.5, no.12, pp.1273 - 1282
Publisher
NATURE PUBLISHING GROUP
Abstract
RNA quality control (RQC) and post-transcriptional gene silencing (PTGS) target and degrade aberrant endogenous RNAs and foreign RNAs, contributing to homeostasis of cellular RNAs. In plants, RQC and PTGS compete for foreign and selected endogenous RNAs; however, little is known about the mechanism interconnecting the two pathways. Using a reporter system designed for monitoring PTGS, we revealed that the 26S proteasome subunit RPT2a enhances transgene PTGS by promoting the accumulation of transgene-derived short interfering RNAs without affecting their biogenesis. RPT2a physically associated with a subset of RQC components and downregulated the protein level. Overexpression of the RQC components interfered with transgene silencing, and impairment of the RQC machinery reinforced transgene PTGS attenuated by rpt2a. Overall, we demonstrate that the 26S proteasome subunit RPT2a promotes PTGS by repressing the RQC machinery to control foreign RNAs.© The Author(s), under exclusive licence to Springer Nature Limited 2019 Nat
URI
https://pr.ibs.re.kr/handle/8788114/6693
ISSN
2055-0278
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Files in This Item:
Nature Plant_5, 1273–1282 (2019).pdfDownload

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