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Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations

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Title
Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations
Author(s)
Park, JC; Bae, JW; Jieun Kim; Min Whan Jung
Publication Date
2019-10
Journal
SCIENTIFIC REPORTS, v.9, no., pp.15512 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Diverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1-7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration. © The Author(s) 2019
URI
https://pr.ibs.re.kr/handle/8788114/6639
ISSN
2045-2322
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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