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시냅스뇌질환연구단
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Dynamically changing neuronal activity supporting working memory for predictable and unpredictable durations

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dc.contributor.authorJong Chan Park-
dc.contributor.authorJung Won Bae-
dc.contributor.authorJieun Kim-
dc.contributor.authorMin Whan Jung-
dc.date.available2019-12-02T05:04:24Z-
dc.date.created2019-11-18-
dc.date.issued2019-10-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6639-
dc.description.abstractDiverse neural processes have been proposed as the neural basis of working memory. To investigate whether the medial prefrontal cortex (mPFC) relies on different neural processes to mediate working memory depending on the predictability of delay duration, we examined mPFC neural activity in mice performing a delayed response task with fixed (4 s) or random (between 1-7 s) delay durations. mPFC neural activity was strongly influenced by the predictability of delay duration. Nevertheless, mPFC neurons seldom showed persistent activity spanning the entire delay period and instead showed dynamically-changing delay-period activity under both the fixed-delay and random-delay conditions. mPFC neurons conveyed higher working memory information under the random-delay than fixed-delay conditions, possibly due to a higher demand for stable working memory maintenance. Our results suggest that the rodent mPFC may rely on dynamically-changing neuronal activity to maintain working memory regardless of the predictability of delay duration. © The Author(s) 2019-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleDynamically changing neuronal activity supporting working memory for predictable and unpredictable durations-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000493048400065-
dc.identifier.scopusid2-s2.0-85074281257-
dc.identifier.rimsid70588-
dc.contributor.affiliatedAuthorJieun Kim-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.doi10.1038/s41598-019-52017-8-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.9, pp.15512-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume9-
dc.citation.startPage15512-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusDELAYED ALTERNATION PERFORMANCE-
dc.subject.keywordPlusMEDIAL PREFRONTAL CORTEX-
dc.subject.keywordPlusUNIT-ACTIVITY-
dc.subject.keywordPlusSEQUENCES-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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