BROWSE

Related Scientist

lee,joonhyuk's photo.

lee,joonhyuk
사회성뇌과학그룹
more info

ITEM VIEW & DOWNLOAD

The rostroventral part of the thalamic reticular nucleus modulates fear extinction

DC Field Value Language
dc.contributor.authorJoon-Hyuk Lee-
dc.contributor.authorCharles-Francois V. Latchoumane-
dc.contributor.authorJungjoon Park-
dc.contributor.authorKim J.-
dc.contributor.authorJeong J.-
dc.contributor.authorLee K.-H.-
dc.contributor.authorHee-Sup Shin-
dc.date.available2019-12-02T05:04:21Z-
dc.date.created2019-10-21-
dc.date.issued2019-10-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6638-
dc.description.abstractThe thalamus has been implicated in fear extinction, yet the role of the thalamic reticular nucleus (TRN) in this process remains unclear. Here, in mice, we show that the rostroventral part of the TRN (TRNrv) is critically involved in the extinction of tone-dependent fear memory. Optogenetic excitation of TRNrv neurons during extinction learning dramatically facilitated, whereas the inhibition disrupted, the fear extinction. Single unit recordings demonstrated that TRNrv neurons selectively respond to conditioned stimuli but not to neutral stimuli. TRNrv neurons suppressed the spiking activity of the medial part of the dorsal midline thalamus (dMTm), and a blockade of this inhibitory pathway disrupted fear extinction. Finally, we found that the suppression of dMTm projections to the central amygdala promotes fear extinction, and TRNrv neurons have direct connections to this pathway. Our results uncover a previously unknown function of the TRN and delineate the neural circuit for thalamic control of fear memory. © The Author(s) 2019-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleThe rostroventral part of the thalamic reticular nucleus modulates fear extinction-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000489705200018-
dc.identifier.scopusid2-s2.0-85073164525-
dc.identifier.rimsid70269-
dc.contributor.affiliatedAuthorJoon-Hyuk Lee-
dc.contributor.affiliatedAuthorCharles-Francois V. Latchoumane-
dc.contributor.affiliatedAuthorJungjoon Park-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.identifier.doi10.1038/s41467-019-12496-9-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.10, no.1, pp.4637-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage4637-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusINFRALIMBIC CORTEX-
dc.subject.keywordPlusPRELIMBIC CORTEX-
dc.subject.keywordPlusCIRCUIT-
dc.subject.keywordPlusHIPPOCAMPAL-
dc.subject.keywordPlusPROJECTIONS-
dc.subject.keywordPlusATTENTION-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusRETRIEVAL-
dc.subject.keywordPlusSELECTION-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > 1. Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
The rostroventral part of the thalamic reticular nucleus modulates fear extinction.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse