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Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins.

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Title
Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins.
Author(s)
Daseuli Yu; Hansol Lee; Jongryul Hong; Hyunjin Jung; YoungJu Jo; Byung-Ha Oh; Byung Ouk Park; Won Do Heo
Publication Date
2019-11
Journal
NATURE METHODS, v.16, no.11, pp.1095 -
Publisher
NATURE PUBLISHING GROUP
Abstract
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.Intracellular antibodies have become powerful tools for imaging, modulating and neutralizing endogenous target proteins. Here, we describe an optogenetically activated intracellular antibody (optobody) consisting of split antibody fragments and blue-light inducible heterodimerization domains. We expanded this optobody platform by generating several optobodies from previously developed intracellular antibodies, and demonstrated that photoactivation of gelsolin and β2-adrenergic receptor (β2AR) optobodies suppressed endogenous gelsolin activity and β2AR signaling, respectively
URI
https://pr.ibs.re.kr/handle/8788114/6636
ISSN
1548-7091
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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