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윤재영
유전체 교정 연구단
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Transcriptional regulatory framework for vascular cambium development in Arabidopsis roots

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Title
Transcriptional regulatory framework for vascular cambium development in Arabidopsis roots
Author(s)
Zhang J.; Eswaran G.; Alonso-Serra J.; Kucukoglu M.; Xiang J.; Yang W.; Elo A.; Nieminen K.; Damen T.; Joung J.-G.; Yun J.-Y.; Lee J.-H.; Ragni L.; Barbier de Reuille P.; Ahnert S.E.; Lee J.-Y.; Mahonen A.P.; Helariutta Y.
Publication Date
2019-10
Journal
NATURE PLANTS, v.5, no.10, pp.1033 - 1042
Publisher
NATURE PUBLISHING GROUP
Abstract
Vascular cambium, a lateral plant meristem, is a central producer of woody biomass. Although a few transcription factors have been shown to regulate cambial activity1, the phenotypes of the corresponding loss-of-function mutants are relatively modest, highlighting our limited understanding of the underlying transcriptional regulation. Here, we use cambium cell-specific transcript profiling followed by a combination of transcription factor network and genetic analyses to identify 62 new transcription factor genotypes displaying an array of cambial phenotypes. This approach culminated in virtual loss of cambial activity when both WUSCHEL-RELATED HOMEOBOX 4 (WOX4) and KNOTTED-like from Arabidopsis thaliana 1 (KNAT1; also known as BREVIPEDICELLUS) were mutated, thereby unlocking the genetic redundancy in the regulation of cambium development. We also identified transcription factors with dual functions in cambial cell proliferation and xylem differentiation, including WOX4, SHORT VEGETATIVE PHASE (SVP) and PETAL LOSS (PTL). Using the transcription factor network information, we combined overexpression of the cambial activator WOX4 and removal of the putative inhibitor PTL to engineer Arabidopsis for enhanced radial growth. This line also showed ectopic cambial activity, thus further highlighting the central roles of WOX4 and PTL in cambium development. © The Author(s), under exclusive licence to Springer Nature Limited 2019
URI
https://pr.ibs.re.kr/handle/8788114/6420
ISSN
2055-0278
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
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