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인지 및 사회성 연구단
인지 및 사회성 연구단
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Histone demethylase PHF2 activates CREB and promotes memory consolidation

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Title
Histone demethylase PHF2 activates CREB and promotes memory consolidation
Author(s)
Kim, HJ; Hur, SW; Park, JB; Seo, J; Jae Jin Shin; Kim, SY; Kim, MH; Han, DH; Park, JW; Joo Min Park; Kim, SJ; Chun, YS
Publication Date
2019-09
Journal
EMBO REPORTS, v.20, no.9, pp.e45907 -
Publisher
WILEY
Abstract
Long-term memory formation is attributed to experience-dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation-related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory-related genes by epigenetically reinforcing the TrkB-CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor-mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long-term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases. ª 2019 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/6361
ISSN
1469-221X
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Social Neuroscience Group(사회성 뇌과학 그룹) > Journal Papers (저널논문)
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
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