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Distinct roles of striatal direct and indirect pathways in value-based decision making

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Title
Distinct roles of striatal direct and indirect pathways in value-based decision making
Author(s)
Shinae Kwak; Min Whan Jung
Publication Date
2019-07
Journal
ELIFE, v.8, no., pp.e46050 -
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Abstract
The striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct-and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making. Copyright Kwak and Jung.
URI
https://pr.ibs.re.kr/handle/8788114/6226
ISSN
2050-084X
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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