BROWSE

Related Scientist

kwak,shinae's photo.

kwak,shinae
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Distinct roles of striatal direct and indirect pathways in value-based decision making

DC Field Value Language
dc.contributor.authorShinae Kwak-
dc.contributor.authorMin Whan Jung-
dc.date.available2019-09-27T01:32:08Z-
dc.date.created2019-08-20-
dc.date.issued2019-07-
dc.identifier.issn2050-084X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6226-
dc.description.abstractThe striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct-and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making. Copyright Kwak and Jung.-
dc.description.uri1-
dc.language영어-
dc.publisherELIFE SCIENCES PUBLICATIONS LTD-
dc.titleDistinct roles of striatal direct and indirect pathways in value-based decision making-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000477604100001-
dc.identifier.scopusid2-s2.0-85071917179-
dc.identifier.rimsid69482-
dc.contributor.affiliatedAuthorShinae Kwak-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.doi10.7554/eLife.46050-
dc.identifier.bibliographicCitationELIFE, v.8, pp.e46050-
dc.citation.titleELIFE-
dc.citation.volume8-
dc.citation.startPagee46050-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusBASAL GANGLIA-
dc.subject.keywordPlusDORSAL STRIATUM-
dc.subject.keywordPlusDOPAMINE-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusREWARD-
dc.subject.keywordPlusREINFORCEMENT-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusMOVEMENT-
dc.subject.keywordPlusFLEXIBILITY-
dc.subject.keywordPlusACTIVATION-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
elife-46050-v2.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse