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Tissue Beads: Tissue-Specific Extracellular Matrix Microbeads to Potentiate Reprogrammed Cell-Based Therapy

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dc.contributor.authorJung Seung Lee-
dc.contributor.authorYoon Ho Roh-
dc.contributor.authorYi Sun Choi-
dc.contributor.authorYoonhee Jin-
dc.contributor.authorEun Je Jeon-
dc.contributor.authorKi Wan Bong-
dc.contributor.authorSeung-Woo Cho-
dc.date.available2019-09-27T01:31:59Z-
dc.date.created2019-05-29-
dc.date.issued2019-08-
dc.identifier.issn1616-301X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/6220-
dc.description.abstract© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Microbeads have been utilized as efficient cell culture carriers and injectable scaffolds for cell transplantation. However, various polymers currently used to generate microbeads have limited applicability due to loss of biological functions and tissue-specific effects. Here, a tissue bead platform is reported that can provide a tissue-specific microenvironment to facilitate cell culture and potentiate cell therapy. Using a flow-focusing microfluidic device, uniform-sized tissue microbeads are fabricated with extracellular matrix (ECM) from various decellularized tissues. The tissue microbeads are tested for tissue-specific encapsulation of induced hepatic (iHep), induced cardiac (iCar), and induced myogenic (iMyo) cells, which are directly reprogrammed from mouse primary fibroblasts. Tissue-specific microbeads significantly enhanced the viability, lineage-specific maturation, and functionality of each type of reprogrammed cell, as compared to functionality when using conventional microbeads from a single ECM component (collagen). Finally, tissue microbeads are confirmed to mediate the successful in vivo engraftment of reprogrammed cells (iHep and iMyo) after transplantation, potentiating cell therapy and promoting functional tissue regeneration in tissue defective animal models. The study suggests that the use of a decellularized tissue matrix combined with a microfluidic technique can be employed to produce tissue-specific ECM microbeads with increased versatility and efficacy for reprogrammed cell-based therapy-
dc.description.uri1-
dc.language영어-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectcell therapy-
dc.subjectdecellularized tissue matrix-
dc.subjectdirect reprogramming-
dc.subjecttissue-specific microbeads-
dc.titleTissue Beads: Tissue-Specific Extracellular Matrix Microbeads to Potentiate Reprogrammed Cell-Based Therapy-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000477977100005-
dc.identifier.scopusid2-s2.0-85065670789-
dc.identifier.rimsid68322-
dc.contributor.affiliatedAuthorSeung-Woo Cho-
dc.identifier.doi10.1002/adfm.201807803-
dc.identifier.bibliographicCitationADVANCED FUNCTIONAL MATERIALS, v.29, no.31, pp.1807803-
dc.citation.titleADVANCED FUNCTIONAL MATERIALS-
dc.citation.volume29-
dc.citation.number31-
dc.citation.startPage1807803-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusFLOW-FOCUSING DEVICE-
dc.subject.keywordPlusDIRECT CONVERSION-
dc.subject.keywordPlusALGINATE MICROBEADS-
dc.subject.keywordPlusHYDROGEL MICROBEADS-
dc.subject.keywordPlusMOUSE FIBROBLASTS-
dc.subject.keywordPlusENCAPSULATION-
dc.subject.keywordPlusMONODISPERSE-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusMICROFLUIDICS-
dc.subject.keywordPlusMICROGELS-
dc.subject.keywordAuthorcell therapy-
dc.subject.keywordAuthordecellularized tissue matrix-
dc.subject.keywordAuthordirect reprogramming-
dc.subject.keywordAuthortissue-specific microbeads-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
201908_Tissue Beads Tissue‐Specific Extracellular Matrix Microbeads to Potentiate Reprogrammed Cell‐Based Therapy_Seung-Woo Cho.pdfDownload

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